NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses

Neutrophils are antigen-transporting cells that generate vaccinia virus (VACV)-specific T-cell responses, yet how VACV modulates neutrophil recruitment and its significance in the immune response are unknown. We generated an attenuated VACV strain that expresses HIV-1 clade C antigens but lacks thre...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Di Pilato, Mauro, Mejías-Pérez, Ernesto, Zonca, Manuela, Perdiguero, Beatriz, Gómez, Carmen Elena, Trakala, Marianna, Nieto, Jacobo, Nájera, José Luis, S. Sorzano, Carlos Oscar, Combadière, Christophe, Pantaleo, Giuseppe, Planelles, Lourdes, Esteban, Mariano
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371968/
https://ncbi.nlm.nih.gov/pubmed/25739961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424341112
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