Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma

High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AK...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Kannan, Kalpana, Coarfa, Cristian, Chao, Pei-Wen, Luo, Liming, Wang, Yan, Brinegar, Amy E., Hawkins, Shannon M., Milosavljevic, Aleksandar, Matzuk, Martin M., Yen, Laising
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371965/
https://ncbi.nlm.nih.gov/pubmed/25733895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501735112
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