Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma

High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AK...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kannan, Kalpana, Coarfa, Cristian, Chao, Pei-Wen, Luo, Liming, Wang, Yan, Brinegar, Amy E., Hawkins, Shannon M., Milosavljevic, Aleksandar, Matzuk, Martin M., Yen, Laising
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371965/
https://ncbi.nlm.nih.gov/pubmed/25733895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501735112
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky