Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma

High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AK...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kannan, Kalpana, Coarfa, Cristian, Chao, Pei-Wen, Luo, Liming, Wang, Yan, Brinegar, Amy E., Hawkins, Shannon M., Milosavljevic, Aleksandar, Matzuk, Martin M., Yen, Laising
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371965/
https://ncbi.nlm.nih.gov/pubmed/25733895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501735112
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