Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase contributes to the development of Alzheimer’s disease. More than 200 disease-derived mutations have been identified in presenilin (the catalytic subunit of γ-secretase), making modulation of γ-secretase activity a potentially attrac...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dang, Shangyu, Wu, Shenjie, Wang, Jiawei, Li, Hongbo, Huang, Min, He, Wei, Li, Yue-Ming, Wong, Catherine C. L., Shi, Yigong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371958/
https://ncbi.nlm.nih.gov/pubmed/25733893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502150112
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