Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage

Amyloid plaques, a neuropathological hallmark of Alzheimer's disease, are largely composed of amyloid β (Aβ) peptide, derived from cleavage of amyloid precursor protein (APP) by β- and γ-secretases. The endosome is increasingly recognized as an important crossroad for APP and these secretases,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Williamson, Rebecca L., Laulagnier, Karine, Miranda, André M., Fernandez, Marty A., Wolfe, Michael S., Sadoul, Rémy, Di Paolo, Gilbert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712626/
https://ncbi.nlm.nih.gov/pubmed/29021256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.818138
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