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Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo

Fluorescence resonance energy transfer-based reporters have been widely used in imaging cell signaling; however, their in vivo application has been handicapped because of poor signal. Although fluorogenic reporters overcome this problem, no such reporter of proteases has been demonstrated for in viv...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: To, Tsz-Leung, Piggott, Beverly J., Makhijani, Kalpana, Yu, Dan, Jan, Yuh Nung, Shu, Xiaokun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371907/
https://ncbi.nlm.nih.gov/pubmed/25733847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502857112
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