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Rational design of a GFP-based fluorogenic caspase reporter for imaging apoptosis in vivo

Fluorescence resonance energy transfer-based executioner caspase reporters using GFP are important tools for imaging apoptosis. While these reporters are useful in imaging apoptosis in cultured cells, their in vivo application has been handicapped by poor signal to noise. Here we report design and c...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: To, Tsz-Leung, Schepis, Antonino, Ruiz-González, Rubén, Zhang, Qiang, Yu, Dan, Dong, Zhiqiang, Coughlin, Shaun R., Shu, Xiaokun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026494/
https://ncbi.nlm.nih.gov/pubmed/27447051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.06.007
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