Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial

BACKGROUND: Human noroviruses (NoVs) are the primary cause of acute gastroenteritis and are characterized by antigenic variation between genogroups and genotypes and antigenic drift of strains within the predominant GII.4 genotype. In the context of this diversity, an effective NoV vaccine must elic...

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Bibliographic Details
Published in:PLoS Med
Main Authors: Lindesmith, Lisa C., Ferris, Martin T., Mullan, Clancy W., Ferreira, Jennifer, Debbink, Kari, Swanstrom, Jesica, Richardson, Charles, Goodwin, Robert R., Baehner, Frank, Mendelman, Paul M., Bargatze, Robert F., Baric, Ralph S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371888/
https://ncbi.nlm.nih.gov/pubmed/25803642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001807
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