Single-Molecule Imaging Reveals that Small Amyloid-β(1–42) Oligomers Interact with the Cellular Prion Protein (PrP(C))

Oligomers of the amyloid-β peptide (Aβ) play a central role in the pathogenesis of Alzheimer’s disease and have been suggested to induce neurotoxicity by binding to a plethora of cell-surface receptors. However, the heterogeneous mixtures of oligomers of varying sizes and conformations formed by Aβ4...

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem
Hauptverfasser: Ganzinger, Kristina A, Narayan, Priyanka, Qamar, Seema S, Weimann, Laura, Ranasinghe, Rohan T, Aguzzi, Adriano, Dobson, Christopher M, McColl, James, St George-Hyslop, Peter, Klenerman, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2014
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371635/
https://ncbi.nlm.nih.gov/pubmed/25294384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402377
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