Unbiased Screening of Marine Sponge Extracts for Anti-Inflammatory Agents Combined with Chemical Genomics Identifies Girolline as an Inhibitor of Protein Synthesis

Toll-like receptors (TLRs) play a critical role in innate immunity, but activation of TLR signaling pathways is also associated with many harmful inflammatory diseases. Identification of novel anti-inflammatory molecules targeting TLR signaling pathways is central to the development of new treatment...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Fung, Shan-Yu, Sofiyev, Vladimir, Schneiderman, Julia, Hirschfeld, Aaron F., Victor, Rachel E., Woods, Kate, Piotrowski, Jeff S., Deshpande, Raamesh, Li, Sheena C., de Voogd, Nicole J., Myers, Chad L., Boone, Charlie, Andersen, Raymond J., Turvey, Stuart E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371607/
https://ncbi.nlm.nih.gov/pubmed/24117378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400740c
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