Dual Inhibition of Allosteric Mitogen-Activated Protein Kinase (MEK) and Phosphatidylinositol 3-Kinase (PI3K) Oncogenic Targets with a Bifunctional Inhibitor

The MAP kinase (Ras/MEK/ERK) and PI3K/Akt/mTOR oncogenic signaling pathways are central regulators of KRAS-mediated transformation. Molecular reciprocity between the Ras/MEK/ERK and PI3K/Akt/mTOR pathways provides cancer cells with the ability to evade treatment when targeting only one pathway with...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Van Dort, Marcian E., Galbán, Stefanie, Wang, Hanxiao, Sebolt-Leopold, Judith, Whitehead, Christopher, Hong, Hao, Rehemtulla, Alnawaz, Ross, Brian D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370322/
https://ncbi.nlm.nih.gov/pubmed/25766633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.053
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