Ocular Toxicity Profile of ST-162 and ST-168 as Novel Bifunctional MEK/PI3K Inhibitors

Purpose: ST-162 and ST-168 are small-molecule bifunctional inhibitors of MEK and PI3K signaling pathways that are being developed as novel antitumor agents. Previous small-molecule and biologic MEK inhibitors demonstrated ocular toxicity events that were dose limiting in clinical studies. We evaluat...

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Publicado no:J Ocul Pharmacol Ther
Main Authors: Smith, Andrew, Pawar, Mercy, Van Dort, Marcian E., Galbán, Stefanie, Welton, Amanda R., Thurber, Greg M., Ross, Brian D., Besirli, Cagri G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088257/
https://ncbi.nlm.nih.gov/pubmed/29708810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2017.0126
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