Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-β–Mediated Collagen Production in a Murine Asthma Model

Asthma is a disease of acute and chronic inflammation in which cytokines play a critical role in orchestrating the allergic inflammatory response. IL-13 and transforming growth factor (TGF)-β promote fibrotic airway remodeling, a major contributor to disease severity. Improved understanding is neede...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Jaffer, Omar A., Carter, A. Brent, Sanders, Philip N., Dibbern, Megan E., Winters, Christopher J., Murthy, Shubha, Ryan, Alan J., Rokita, Adam G., Prasad, Anand M., Zabner, Joseph, Kline, Joel N., Grumbach, Isabella M., Anderson, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370251/
https://ncbi.nlm.nih.gov/pubmed/24988374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0519OC
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