CD4(+) T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

Th17 cells contribute to severe GVHD in murine bone marrow transplantation. Targeted deletion of the RORγt transcription factor or blockade of the JAK2-STAT3 axis suppresses IL-17 production and alloreactivity by Th17 cells. Here, we show that pSTAT3 Y705 is increased significantly in CD4(+) T cells...

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Detalles Bibliográficos
Publicado en:J Leukoc Biol
Main Authors: Betts, Brian C., Sagatys, Elizabeth M., Veerapathran, Anandharaman, Lloyd, Mark C., Beato, Francisca, Lawrence, Harshani R., Yue, Binglin, Kim, Jongphil, Sebti, Said M., Anasetti, Claudio, Pidala, Joseph
Formato: Artigo
Idioma:Inglês
Publicado: Society for Leukocyte Biology 2015
Assuntos:
Translational & Clinical Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370048/
https://ncbi.nlm.nih.gov/pubmed/25663681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1114-532RR
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