CD4(+) T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

Th17 cells contribute to severe GVHD in murine bone marrow transplantation. Targeted deletion of the RORγt transcription factor or blockade of the JAK2-STAT3 axis suppresses IL-17 production and alloreactivity by Th17 cells. Here, we show that pSTAT3 Y705 is increased significantly in CD4(+) T cells...

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Vydáno v:J Leukoc Biol
Hlavní autoři: Betts, Brian C., Sagatys, Elizabeth M., Veerapathran, Anandharaman, Lloyd, Mark C., Beato, Francisca, Lawrence, Harshani R., Yue, Binglin, Kim, Jongphil, Sebti, Said M., Anasetti, Claudio, Pidala, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2015
Témata:
Translational & Clinical Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370048/
https://ncbi.nlm.nih.gov/pubmed/25663681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5A1114-532RR
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