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STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity
Alloreactivity negatively influences outcomes of organ transplantation or HCT from allogeneic donors. Standard pharmacologic immune suppression impairs T-cell function and jeopardizes the beneficial reconstitution of Tregs. Murine transplantation models have shown that STAT3 is highly expressed in a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Leukocyte Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896660/ https://ncbi.nlm.nih.gov/pubmed/24068731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313154 |
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