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STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity

Alloreactivity negatively influences outcomes of organ transplantation or HCT from allogeneic donors. Standard pharmacologic immune suppression impairs T-cell function and jeopardizes the beneficial reconstitution of Tregs. Murine transplantation models have shown that STAT3 is highly expressed in a...

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Detalhes bibliográficos
Main Authors: Betts, Brian C., Veerapathran, Anandharaman, Pidala, Joseph, Yu, Xue-Zhong, Anasetti, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896660/
https://ncbi.nlm.nih.gov/pubmed/24068731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313154
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