NEDD9/Arf6-Dependent Endocytic Trafficking of Matrix Metalloproteinase 14: A Novel Mechanism for Blocking Mesenchymal Cell Invasion and Metastasis of Breast Cancer

NEDD9 is an established marker of invasive and metastatic cancers. NEDD9 downregulation has been shown to dramatically reduce cell invasion and metastasis in multiple tumors. The mechanisms by which NEDD9 regulates invasion are largely unknown. In the current study, we have found that NEDD9 is requi...

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Veröffentlicht in:Oncogene
Hauptverfasser: Loskutov, Yuriy V., Kozyulina, Polina Y., Kozyreva, Varvara K., Ice, Ryan J., Jones, Brandon C., Roston, Trevor J., Smolkin, Matthew B., Ivanov, Alexey V., Wysolmerski, Robert B., Pugacheva, Elena N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369482/
https://ncbi.nlm.nih.gov/pubmed/25241893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.297
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