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NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors

Aurora A Kinase (AURKA) is overexpressed in 96% of human cancers and is considered an independent marker of poor prognosis. While the majority of tumors have elevated levels of AURKA protein, few have AURKA gene amplification, implying that posttranscriptional mechanism regulating AURKA protein leve...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ice, Ryan J., McLaughlin, Sarah L., Livengood, Ryan H., Culp, Mark V., Eddy, Erik R., Ivanov, Alexey V., Pugacheva, Elena N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667743/
https://ncbi.nlm.nih.gov/pubmed/23539442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4008
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