NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors

Aurora A Kinase (AURKA) is overexpressed in 96% of human cancers and is considered an independent marker of poor prognosis. While the majority of tumors have elevated levels of AURKA protein, few have AURKA gene amplification, implying that posttranscriptional mechanism regulating AURKA protein leve...

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Detaylı Bibliyografya
Asıl Yazarlar: Ice, Ryan J., McLaughlin, Sarah L., Livengood, Ryan H., Culp, Mark V., Eddy, Erik R., Ivanov, Alexey V., Pugacheva, Elena N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667743/
https://ncbi.nlm.nih.gov/pubmed/23539442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4008
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