A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively. The molecular mechanism that underlies this dual substrate specificity has remained unknown. Here we report that an isoform of LSD1,...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Laurent, Benoit, Ruitu, Lv, Murn, Jernej, Hempel, Kristina, Ferrao, Ryan, Xiang, Yang, Liu, Shichong, Garcia, Benjamin A., Wu, Hao, Wu, Feizhen, Steen, Hanno, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369399/
https://ncbi.nlm.nih.gov/pubmed/25684206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.010
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