The histone demethylase LSD1/KDM1A promotes the DNA damage response

Histone demethylation is known to regulate transcription, but its role in other processes is largely unknown. We report a role for the histone demethylase LSD1/KDM1A in the DNA damage response (DDR). We show that LSD1 is recruited directly to sites of DNA damage. H3K4 dimethylation, a major substrat...

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Detalhes bibliográficos
Main Authors: Mosammaparast, Nima, Kim, Haeyoung, Laurent, Benoit, Zhao, Yu, Lim, Hui Jun, Majid, Mona C., Dango, Sebastian, Luo, Yuying, Hempel, Kristina, Sowa, Mathew E., Gygi, Steven P., Steen, Hanno, Harper, J. Wade, Yankner, Bruce, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824007/
https://ncbi.nlm.nih.gov/pubmed/24217620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302092
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