Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation

BACKGROUND: T-cell targeted peptide epitope tolerogens from grass pollen allergens may be useful in treating seasonal allergic rhinitis, but there is urgent need for optimisation of approaches from improved understanding of mechanism. OBJECTIVE: We sought to identify human leukocyte antigen (HLA)-DR...

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Veröffentlicht in:Thorax
Hauptverfasser: Till, Stephen J, Raynsford, Eleanor J, Reynolds, Catherine J, Quigley, Kathryn J, Grzybowska-Kowalczyk, Agnieszka, Saggar, Lavina R, Goldstone, Andrea, Maillere, Bernard, Kwok, William W, Altmann, Daniel M, Durham, Stephen R, Boyton, Rosemary J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368902/
https://ncbi.nlm.nih.gov/pubmed/24258832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2013-204324
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