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Cbl-b and Itch: Key regulators of peripheral T cell tolerance
E3 ligases Cbl-b and Itch have emerged as dominant “tolerogenic” regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T cell anergy and development of Foxp3+ Tregs in the periphery by modulating key components of TCR and TGF-β...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856114/ https://ncbi.nlm.nih.gov/pubmed/20395198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4076 |
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