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Excitotoxic Insult Results in a Long-Lasting Activation of CaMKIIα and Mitochondrial Damage in Living Hippocampal Neurons
Over-activation of excitatory NMDA receptors and the resulting Ca(2+) overload is the main cause of neuronal toxicity during stroke. CaMKII becomes misregulated during such events. Biochemical studies show either a dramatic loss of CaMKII activity or its persistent autonomous activation after stroke...
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| Vydáno v: | PLoS One |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4368532/ https://ncbi.nlm.nih.gov/pubmed/25793533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120881 |
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