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Excitotoxic Insult Results in a Long-Lasting Activation of CaMKIIα and Mitochondrial Damage in Living Hippocampal Neurons
Over-activation of excitatory NMDA receptors and the resulting Ca(2+) overload is the main cause of neuronal toxicity during stroke. CaMKII becomes misregulated during such events. Biochemical studies show either a dramatic loss of CaMKII activity or its persistent autonomous activation after stroke...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4368532/ https://ncbi.nlm.nih.gov/pubmed/25793533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120881 |
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