Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design

The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes. The polymorphic nature of DBP induces strain-specific immune responses that pose unique challenges for vaccine development. DEKnull is a synthetic DBP based antigen that...

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Detalles Bibliográficos
Publicado en:PLoS Negl Trop Dis
Autores principales: Chen, Edwin, Salinas, Nichole D., Ntumngia, Francis B., Adams, John H., Tolia, Niraj H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368114/
https://ncbi.nlm.nih.gov/pubmed/25793371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003644
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