A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism

Producing pure and well behaved bispecific antibodies (bsAbs) on a large scale for preclinical and clinical testing is a challenging task. Here, we describe a new strategy for making monovalent bispecific heterodimeric IgG antibodies in mammalian cells. We applied an electrostatic steering mechanism...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Liu, Zhi, Leng, Esther C., Gunasekaran, Kannan, Pentony, Martin, Shen, Min, Howard, Monique, Stoops, Janelle, Manchulenko, Kathy, Razinkov, Vladimir, Liu, Hua, Fanslow, William, Hu, Zhonghua, Sun, Nancy, Hasegawa, Haruki, Clark, Rutilio, Foltz, Ian N., Yan, Wei
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2015
विषय:
Immunology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367261/
https://ncbi.nlm.nih.gov/pubmed/25583986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620260
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