Asymmetrical Fc Engineering Greatly Enhances Antibody-dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies

Antibody-dependent cellular cytotoxicity (ADCC) is mediated through the engagement of the Fc segment of antibodies with Fcγ receptors (FcγRs) on immune cells upon binding of tumor or viral antigen. The co-crystal structure of FcγRIII in complex with Fc revealed that Fc binds to FcγRIII asymmetricall...

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Detalhes bibliográficos
Main Authors: Liu, Zhi, Gunasekaran, Kannan, Wang, Wei, Razinkov, Vladimir, Sekirov, Laura, Leng, Esther, Sweet, Heather, Foltz, Ian, Howard, Monique, Rousseau, Anne-Marie, Kozlosky, Carl, Fanslow, William, Yan, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916558/
https://ncbi.nlm.nih.gov/pubmed/24311787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513366
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