Structural basis of a novel heterodimeric Fc for bispecific antibody production

Bispecific antibodies provide an efficient tool for combinational clinical therapy. Here we have engineered a heterodimeric Fc for bispecific antibodies production by combining the knob-into-hole and electrostatic steering strategies where a bulky hydrophobic residue Phe405 of the IgG CH3 interface...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Wei, Hudie, Cai, Haiyan, Jin, Yuhao, Wang, Pilin, Zhang, Qingqing, Lin, Yihui, Wang, Weixiao, Cheng, Jinke, Zeng, Naiyan, Xu, Ting, Zhou, Aiwu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584228/
https://ncbi.nlm.nih.gov/pubmed/28881627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17558
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