Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab

Monoclonal antibodies targeting PD-1/PD-L1 signaling pathway have achieved unprecedented success in cancer treatment over the last few years. Atezolizumab is the first PD-L1 monoclonal antibody approved by US FDA for cancer therapy; however the molecular basis of atezolizumab in blocking PD-1/PD-L1...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Fei, Qi, Xiaoqiang, Wang, Xiaoxiao, Wei, Diyang, Wu, Jiawei, Feng, Lingling, Cai, Haiyan, Wang, Yugang, Zeng, Naiyan, Xu, Ting, Zhou, Aiwu, Zheng, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685743/
https://ncbi.nlm.nih.gov/pubmed/29163822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21652
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