The E3 Ubiquitin Ligase Parkin Is Recruited to the 26 S Proteasome via the Proteasomal Ubiquitin Receptor Rpn13

Mutations in the Park2 gene, encoding the RING-HECT hybrid E3 ubiquitin ligase parkin, are responsible for a common familial form of Parkinson disease. By mono- and polyubiquitinating target proteins, parkin regulates various cellular processes, including degradation of proteins within the 26 S prot...

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Udgivet i:J Biol Chem
Main Authors: Aguileta, Miguel A., Korac, Jelena, Durcan, Thomas M., Trempe, Jean-François, Haber, Michael, Gehring, Kalle, Elsasser, Suzanne, Waidmann, Oliver, Fon, Edward A., Husnjak, Koraljka
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367258/
https://ncbi.nlm.nih.gov/pubmed/25666615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614925
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