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Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

N-Methyl-d-aspartate receptors (NMDARs) are inhibited by behaviorally relevant concentrations of ethanol, and residues within transmembrane (TM) domains of NMDARs, including TM3 GluN1 phenylalanine 639 (F639), regulate this sensitivity. In the present study, we used cysteine (C) mutagenesis to deter...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Xu, Minfu, Smothers, C. Thetford, Woodward, John J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366756/
https://ncbi.nlm.nih.gov/pubmed/25635140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.222034
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