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Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

N-Methyl-d-aspartate receptors (NMDARs) are inhibited by behaviorally relevant concentrations of ethanol, and residues within transmembrane (TM) domains of NMDARs, including TM3 GluN1 phenylalanine 639 (F639), regulate this sensitivity. In the present study, we used cysteine (C) mutagenesis to deter...

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Publicat a:J Pharmacol Exp Ther
Autors principals: Xu, Minfu, Smothers, C. Thetford, Woodward, John J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366756/
https://ncbi.nlm.nih.gov/pubmed/25635140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.222034
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