Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8(+) T-Cell Response

BACKGROUND: Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8(+) T-cell abnormalities and CD8-enriched myocarditis occurring in an inflammatory milieu. Pentoxifylline (PTX), a phosphodiesterase inhibitor, has immunoregulatory and cardiop...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Pereira, Isabela Resende, Vilar-Pereira, Glaucia, Moreira, Otacilio Cruz, Ramos, Isalira Peroba, Gibaldi, Daniel, Britto, Constança, Moraes, Milton Ozório, Lannes-Vieira, Joseli
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366205/
https://ncbi.nlm.nih.gov/pubmed/25789471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003659
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