Local Hydrogel Release of Recombinant TIMP-3 Attenuates Adverse Left Ventricular Remodeling After Experimental Myocardial Infarction

An imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) contributes to the left ventricle (LV) remodeling that occurs after myocardial infarction (MI). However, translation of these observations into a clinically relevant, therapeutic strategy remains to be establ...

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Published in:Sci Transl Med
Main Authors: Eckhouse, Shaina R., Purcell, Brendan P., McGarvey, Jeremy R., Lobb, David, Logdon, Christina B., Doviak, Heather, O’Neill, Jason W., Shuman, James A., Novack, Craig P., Zellars, Kia N., Pettaway, Sara, Black, Roy A., Khakoo, Aarif, Lee, TaeWeon, Mukherjee, Rupak, Gorman, Joseph H., Gorman, Robert C., Burdick, Jason A., Spinale, Francis G.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365799/
https://ncbi.nlm.nih.gov/pubmed/24523321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007244
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