Identification of HDAC Inhibitors with Benzoylhydrazide scaffold that Selectively Inhibit Class I HDACs

Inhibitors of histone deacetylases (HDACi) hold a considerable therapeutic promise as clinical anticancer therapies. However, currently known HDACi exhibit limited isoform specificity, off-target activity, and undesirable pharmaceutical properties. Thus, HDACi with new chemotypes are needed to overc...

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Detalhes bibliográficos
Publicado no:Chem Biol
Main Authors: Wang, Yunfei, Stowe, Ryan L., Pinello, Christie E., Tian, Guimei, Madoux, Franck, Li, Dawei, Zhao, Lisa Y., Li, Jian-Liang, Wang, Yuren, Wang, Yuan, Ma, Haiching, Hodder, Peter, Roush, William R., Liao, Daiqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365786/
https://ncbi.nlm.nih.gov/pubmed/25699604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.12.015
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