Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart

Percutaneous coronary intervention is first-line therapy for acute coronary syndromes (ACS) but can promote cardiomyocyte death and cardiac dysfunction via reperfusion injury, a phenomenon driven in large part by oxidative stress. Therapies to limit this progression have proven elusive, with no majo...

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Publicado no:Sci Transl Med
Main Authors: Vagnozzi, Ronald J., Gatto, Gregory J., Kallander, Lara S., Hoffman, Nicholas E., Mallilankaraman, Karthik, Ballard, Victoria L. T., Lawhorn, Brian G., Stoy, Patrick, Philp, Joanne, Graves, Alan P., Naito, Yoshiro, Lepore, John J., Gao, Erhe, Madesh, Muniswamy, Force, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365498/
https://ncbi.nlm.nih.gov/pubmed/24132636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006479
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