Enhancement of MHC-I Antigen Presentation via Architectural Control of pH-Responsive, Endosomolytic Polymer Nanoparticles

Protein-based vaccines offer a number of important advantages over organism-based vaccines but generally elicit poor CD8(+) T cell responses. We have previously demonstrated that pH-responsive, endosomolytic polymers can enhance protein antigen delivery to major histocompatibility complex class I (M...

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Publicat a:AAPS J
Autors principals: Wilson, John T., Postma, Almar, Keller, Salka, Convertine, Anthony J., Moad, Graeme, Rizzardo, Ezio, Meagher, Laurence, Chiefari, John, Stayton, Patrick S.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365097/
https://ncbi.nlm.nih.gov/pubmed/25501498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9697-1
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