Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

Chaperone-mediated autophagy (CMA), a cellular process that contributes to protein quality control through targeting of a subset of cytosolic proteins to lysosomes for degradation, undergoes a functional decline with age. We have used a mouse model with liver-specific defective CMA to identify chang...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Aging Cell
Hlavní autoři: Schneider, Jaime L, Villarroya, Joan, Diaz-Carretero, Antonio, Patel, Bindi, Urbanska, Aleksandra M, Thi, Mia M, Villarroya, Francesc, Santambrogio, Laura, Cuervo, Ana Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364837/
https://ncbi.nlm.nih.gov/pubmed/25620427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12310
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky