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Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging
Chaperone-mediated autophagy (CMA), a cellular process that contributes to protein quality control through targeting of a subset of cytosolic proteins to lysosomes for degradation, undergoes a functional decline with age. We have used a mouse model with liver-specific defective CMA to identify chang...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364837/ https://ncbi.nlm.nih.gov/pubmed/25620427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12310 |
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