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Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation
The activity of chaperone-mediated autophagy (CMA), a catabolic pathway for selective degradation of cytosolic proteins in lysosomes, decreases with age, but the consequences of this functional decline in vivo remain unknown. In this work, we have generated a conditional knockout mouse to selectivel...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156578/ https://ncbi.nlm.nih.gov/pubmed/25043815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.06.009 |
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