Local Production of the Alternative Pathway Component Factor B Is Sufficient to Promote Laser-Induced Choroidal Neovascularization

PURPOSE. Complement factor B (CFB) is a required component of the alternative pathway (AP) of complement, and CFB polymorphisms are associated with age-related macular degeneration (AMD) risk. Complement factor B is made in the liver, but expression has also been detected in retina and retinal pigme...

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Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Schnabolk, Gloriane, Coughlin, Beth, Joseph, Kusumam, Kunchithapautham, Kannan, Bandyopadhyay, Mausumi, O'Quinn, Elizabeth C., Nowling, Tamara, Rohrer, Bärbel
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364641/
https://ncbi.nlm.nih.gov/pubmed/25593023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15910
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