Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

BACKGROUND: Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA co...

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Publicado en:BMC Cancer
Autores principales: Birgisson, Helgi, Edlund, Karolina, Wallin, Ulrik, Påhlman, Lars, Kultima, Hanna Göransson, Mayrhofer, Markus, Micke, Patrick, Isaksson, Anders, Botling, Johan, Glimelius, Bengt, Sundström, Magnus
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364587/
https://ncbi.nlm.nih.gov/pubmed/25884297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1144-x
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