Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

BACKGROUND: Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA co...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Birgisson, Helgi, Edlund, Karolina, Wallin, Ulrik, Påhlman, Lars, Kultima, Hanna Göransson, Mayrhofer, Markus, Micke, Patrick, Isaksson, Anders, Botling, Johan, Glimelius, Bengt, Sundström, Magnus
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364587/
https://ncbi.nlm.nih.gov/pubmed/25884297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1144-x
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