Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

BACKGROUND: Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA co...

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Pubblicato in:BMC Cancer
Autori principali: Birgisson, Helgi, Edlund, Karolina, Wallin, Ulrik, Påhlman, Lars, Kultima, Hanna Göransson, Mayrhofer, Markus, Micke, Patrick, Isaksson, Anders, Botling, Johan, Glimelius, Bengt, Sundström, Magnus
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364587/
https://ncbi.nlm.nih.gov/pubmed/25884297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1144-x
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