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Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters

Small-molecule inhibitors of urea transporter (UT) proteins in kidney have potential application as novel salt-sparing diuretics. The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa rec...

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Vydáno v:Biochim Biophys Acta
Hlavní autoři: Esteva-Font, Cristina, Phuan, Puay-Wah, Lee, Sujin, Su, Tao, Anderson, Marc O., Verkman, A. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364388/
https://ncbi.nlm.nih.gov/pubmed/25613743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2015.01.004
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