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Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters
Small-molecule inhibitors of urea transporter (UT) proteins in kidney have potential application as novel salt-sparing diuretics. The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa rec...
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| Publicado en: | Biochim Biophys Acta |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364388/ https://ncbi.nlm.nih.gov/pubmed/25613743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2015.01.004 |
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