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Triazolothienopyrimidine Inhibitors of Urea Transporter UT-B Reduce Urine Concentration
Urea transport (UT) proteins facilitate the concentration of urine by the kidney, suggesting that inhibition of these proteins could have therapeutic use as a diuretic strategy. We screened 100,000 compounds for UT-B inhibition using an optical assay based on the hypotonic lysis of acetamide-loaded...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Nephrology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380644/ https://ncbi.nlm.nih.gov/pubmed/22491419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011070751 |
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