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Triazolothienopyrimidine Inhibitors of Urea Transporter UT-B Reduce Urine Concentration

Urea transport (UT) proteins facilitate the concentration of urine by the kidney, suggesting that inhibition of these proteins could have therapeutic use as a diuretic strategy. We screened 100,000 compounds for UT-B inhibition using an optical assay based on the hypotonic lysis of acetamide-loaded...

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Détails bibliographiques
Auteurs principaux: Yao, Chenjuan, Anderson, Marc O., Zhang, Jicheng, Yang, Baoxue, Phuan, Puay-Wah, Verkman, A.S.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380644/
https://ncbi.nlm.nih.gov/pubmed/22491419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011070751
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