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Nanomolar Potency and Metabolically Stable Inhibitors of Kidney Urea Transporter UT-B
Urea transporters, which include UT-B in kidney microvessels, are potential targets for development of drugs with a novel diuretic (‘urearetic’) mechanism. We recently identified, by high-throughput screening, a triazolothienopyrimidine UT-B inhibitor, 1, that selectively and reversibly inhibited ur...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590912/ https://ncbi.nlm.nih.gov/pubmed/22694147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300491y |
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