Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats

Inhibitors of kidney urea transporter (UT) proteins have potential use as salt-sparing diuretics (‘urearetics’) with a different mechanism of action than diuretics that target salt transporters. To study UT inhibition in rats, we screened about 10,000 drugs, natural products and urea analogs for inh...

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Bibliografiska uppgifter
I publikationen:Kidney Int
Huvudupphovsmän: Cil, Onur, Esteva-Font, Cristina, Tas, Sadik Taskin, Su, Tao, Lee, Sujin, Anderson, Marc O., Ertunc, Mert, Verkman, A. S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523423/
https://ncbi.nlm.nih.gov/pubmed/25993324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2015.138
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