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Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn) into toxic oligomers and amyloids is important for the drug development against Parkinson's disease. However the structural and morphological characterization during nucleation and subsequent fibrillation pr...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4363886/ https://ncbi.nlm.nih.gov/pubmed/25784353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09228 |
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