Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague

Previously, we showed that deletion of genes encoding Braun lipoprotein (Lpp) and MsbB attenuated Yersinia pestis CO92 in mouse and rat models of bubonic and pneumonic plague. While Lpp activates Toll-like receptor 2, the MsbB acyltransferase modifies lipopolysaccharide. Here, we deleted the ail gen...

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Detaylı Bibliyografya
Yayımlandı:Infect Immun
Asıl Yazarlar: Tiner, Bethany L., Sha, Jian, Kirtley, Michelle L., Erova, Tatiana E., Popov, Vsevolod L., Baze, Wallace B., van Lier, Christina J., Ponnusamy, Duraisamy, Andersson, Jourdan A., Motin, Vladimir L., Chauhan, Sadhana, Chopra, Ashok K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Molecular Pathogenesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363438/
https://ncbi.nlm.nih.gov/pubmed/25605764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02778-14
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