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Seamless Phase I/II Adaptive Design For Oncology Trials of Molecularly Targeted Agents

In dose-finding trials of chemotherapeutic agents, the goal of identifying the maximum tolerated dose is usually determined by considering information on toxicity only, with the assumption that the highest safe dose also provides the most promising outlook for efficacy. Trials of molecularly targete...

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Bibliografiska uppgifter
I publikationen:J Biopharm Stat
Huvudupphovsmän: Wages, Nolan A., Tait, Christopher
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363077/
https://ncbi.nlm.nih.gov/pubmed/24904956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2014.920873
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